Modeling TCR Signaling Complex Formation
نویسندگان
چکیده
منابع مشابه
Cutting edge: Evidence for a dynamically driven T cell signaling mechanism.
T cells use the αβ TCR to bind peptides presented by MHC proteins (pMHC) on APCs. Formation of a TCR-pMHC complex initiates T cell signaling via a poorly understood process, potentially involving changes in oligomeric state, altered interactions with CD3 subunits, and mechanical stress. These mechanisms could be facilitated by binding-induced changes in the TCR, but the nature and extent of any...
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تاریخ انتشار 2003